Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00615628

Enrollment

Registered

2008-02-14

Start date

2002-04-30

Completion date

2009-12-31

Last updated

2013-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteosarcoma, Paget's Disease

Keywords

Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18

Brief summary

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Detailed description

As above, no additional information

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* This is a familial study therefore the only inclusion/

Exclusion criteria

would be that subjects must be a blood relative and over the age of 18. * The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

Design outcomes

Primary

Measure	Time frame	Description
Loss of heterozygosity	January, 2000 through February 2009	A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18

Countries

United States

Outcome results