Advanced MRI in Major Depression

Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00613912

Enrollment

Registered

2008-02-13

Start date

2008-03-31

Completion date

2011-06-30

Last updated

2011-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive Disorder, Major

Keywords

Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Perfusion, brain

Brief summary

Depression is the most common psychiatric disorder. * 3-5% of a given population has major depression. * Less than 50% of the depressed in Denmark are diagnosed with major depression. * 25-50% of the depressed have a relative with major depression-underlying brain pathology? The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Detailed description

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed. MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Interventions

OTHERMagnetic Resonance Imaging

* Morphological sequences * Arterial Spin Labelling (Perfusion) * Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion criteria

* If the patient has pacemaker or other magnetic devices * Pregnancy * Has had an operation in the brain * bipolar disorder

Design outcomes

Primary

Measure	Time frame
Differences in morphological and functional cerebral MRI findings in patients suffering from major depression	6 months from first MRI in each patient

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026