Antioxidant Supplementation in Trauma Patients

Status

Terminated

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00613392

Enrollment

Registered

2008-02-13

Start date

2007-11-30

Completion date

2009-11-30

Last updated

2016-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Trauma

Keywords

antioxidant, oxidant stress, trauma, free radical

Brief summary

Administration of antioxidants to trauma patients will improve measures of oxidant stress in the blood

Interventions

DIETARY_SUPPLEMENTpowdered antioxidant

one vial mixed with water every day orally or through enteral tube

DIETARY_SUPPLEMENTpowdered cornstarch placebo

one vial mix with water and administer orally or via enteral tube

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Adult non pregnant non lactating trauma patient

Exclusion criteria

* GCS \<6 * Renal dysfunction (cre \> 2.5 mg/dl) * Hepatic dysfunction ( TBili \> 3.0 mg/dl) * Expected survival \< 48 hours * Burns over \> 20% body surface area * Immune-deficiency syndromes * Steroid use

Design outcomes

Primary

Measure	Time frame
measures of malondialdehyde level/total antioxidant status and F2 isoprostane	7 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026