Type 2 Diabetes
Conditions
Brief summary
The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.
Interventions
DRUGglucagon-like peptide-1,
GLP-1:continuous infusion of ½ pmol/kg/min for a total time of 120 minutes.
continuous infusion of GIP (1½ pmol/kg/min) for 120 min.
DRUGSaline
continuous infusion of Saline for 120 min
Sponsors
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-70 years * Type 2 diabetes diagnosed after 30 years of age * BMI \> 25
Exclusion criteria
* Severe complications to diabetes * Abnormal liver and kidney function * Haemoglobin below the lower limit * Macroalbuminuria * Systemic disease * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2.phase insulin response measured as incremental area under the curve from 10-120 minutes | 2 hours |
Secondary
| Measure | Time frame |
|---|---|
| 2.phase insulin response measured as incremental area under the curve from 10-120 minutes, after 4 weeks of insulin treatment | 2 hours |
Countries
Denmark
Outcome results
None listed