Diabetes Mellitus Type 2
Conditions
Brief summary
The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1
Interventions
continuous infusion of GLP-1 (1½ pmol/kg/min)
DRUGSaline
continuous infusion of saline
Sponsors
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-70 years * Type 2 diabetes diagnosed after 30 years of age * BMI \> 25
Exclusion criteria
* Severe complications to diabetes * Abnormal liver og kidney function * Haemoglobin below the lower limit * Macroalbuminuria * Systemic disease * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| insulin secretion rate (ISR) were derived by deconvolution of c-peptide. ISR is expressed as pmol/kg/min | 180 minutes |
Secondary
| Measure | Time frame |
|---|---|
| The calculated ISR values was plotted against the ambient plasma glucose. The slopes of this linear relationships were calculated by cross-correlation analysis and is and estimation of beta-cell responsiveness (pmol/kg/min)/mmol/l | 180 minutes |
Countries
Denmark
Outcome results
None listed