GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

Gamma-Aminobutyric Acid (GABA) Mechanisms Underlying the Vulnerability to Alcohol Dependence

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00611767

Enrollment

Registered

2008-02-11

Start date

2005-11-30

Completion date

2012-04-30

Last updated

2017-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcoholism

Keywords

Thiopental, Alcohol, Family History, Vulnerability, GABA

Brief summary

This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward valence (balance of positive and negative effects) of the GABAA receptor agonist barbiturate (thiopental) compared to family history negative age-matched subjects. Further, variation in genes involved in brain GABA function may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol.

Detailed description

This project will explore the hypothesis that individuals with a family history positive for alcohol dependence (FHP) (without any current DSM-IV Axis I disorder, except nicotine dependence), experience an alteration in the reward valence (balance of positive and negative effects) of the GABA-A receptor agonist barbiturate (thiopental) compared to family history negative (FHN) age-matched subjects. Further, the effect of variations in genes important in regulating brain GABA function may alter a component of the discriminative stimulus effects of ethanol. FHP individuals are defined as individuals with at least one first-degree relative and another first- or second-degree relatives. Preliminary results suggest that FHP individuals showed an attenuated response to thiopental as measured by the descending limb of the BAES during thiopental infusion relative to the FHN group. Further, preliminary results suggest that variation in genes involved in brain GABA function, glutamate decarboxylase-65 (GAD65), may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol. We plan to recruit 2 groups of healthy subjects between the ages of 21-30, one with a family history of alcoholism (family history positive=FHP) and a sex-matched control group without a family history of alcoholism (family history negative=FHN), to undergo two test days scheduled 3 days apart, in a randomized double-blind fashion. Test days will involve a 60-minute intravenous infusion of each of 2 conditions: saline or thiopental, in a randomized order under double-blind conditions. Behavioral ratings include the Biphasic Alcohol Effects Scale (BAES) and Visual Analog Scales (VAS). Exploratory measures include event-related potential recordings (ERP) and measures of eye-to-hand coordination. Blood will be collected for Deoxyribonucleic acid (DNA) extraction and genotyping.

Interventions

DRUGThiopental

A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion).

DRUGPlacebo

A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion).

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

21 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

1. Male and female between the ages of 21 and 30 years 2. medically and neurologically healthy on the basis of history, physical examination, Electrocardiogram (EKG), screening laboratories 3. absence of any evidence of substance abuse (with the exception of nicotine dependence) on the basis of history and drug and ethanol-free at the time of testing based on urine toxicology and breath alcohol levels at screening and on each test day.

Exclusion criteria

1. Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) Axis I psychiatric and substance abuse or dependence diagnosis by history on psychiatric evaluation that includes a structured diagnostic interview (SCID) 2. unwillingness to remain alcohol-free for three days prior to each test day; 3. for women, positive pregnancy test at screening or intention to engage in unprotected sex during the study and 4. alcohol naive. For Family History Positive Subjects: 1) Biological father and another first or second-degree biological relative with history of alcoholism by Family History Assessment Module (FHAM) developed by The Collaborative Study on the Genetics of Alcoholism (COGA). For Family History Negative Subjects: NO family history of alcoholism in any first or second-degree relatives. Subjects must reliably report on three first-degree relatives.

Design outcomes

Primary

Measure	Time frame	Description
Visual Analog Scales of Similarity to Alcohol - Baseline	Baseline	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 15 Minutes	15 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 45 Minutes	45 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 80 Minutes	80 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 110 Minutes	110 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 170 Minutes	170 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Visual Analog Scales of Similarity to Alcohol - 230 Minutes	230 minutes	Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Secondary

Measure	Time frame	Description
Number of Drinks Felt Consumed - 230 Minutes	230 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline	Baseline	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes	15 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes	45 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes	80 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes	110 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes	170 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes	230 minutes	Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline	Baseline	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes	15 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes	45 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes	80 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes	170 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes	230 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Visual Analog Scales (VAS) - High - Baseline	Baseline	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 15 Minutes	15 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 45 Minutes	45 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 80 Minutes	80 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 110 Minutes	110 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 170 Minutes	170 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - High - 230 Minutes	230 minutes	visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)
Visual Analog Scales (VAS) - Buzzed - Baseline	Baseline	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Buzzed - 15 Minutes	15 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Buzzed - 45 Minutes	45 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Buzzed - 80 Minutes	80 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) .
Visual Analog Scales (VAS) - Buzzed - 110 Minutes	110 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Buzzed - 170 Minutes	170 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Buzzed - 230 Minutes	230 minutes	visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)
Visual Analog Scales (VAS) - Drowsy - Baseline	Baseline	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Drowsy - 15 Minutes	15 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Drowsy - 45 Minutes	45 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) .
Visual Analog Scales (VAS) - Drowsy - 80 Minutes	80 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Drowsy - 110 Minutes	110 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Drowsy - 170 Minutes	170 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Drowsy - 230 Minutes	230 minutes	visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)
Visual Analog Scales (VAS) - Depressed - Baseline	Baseline	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 15 Minutes	15 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 45 Minutes	45 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 80 Minutes	80 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 110 Minutes	110 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 170 Minutes	170 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Depressed - 230 Minutes	230 minutes	visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)
Visual Analog Scales (VAS) - Anxious - Baseline	Baseline	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 15 Minutes	15 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 45 Minutes	45 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 80 Minutes	80 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 110 Minutes	110 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 170 Minutes	170 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Visual Analog Scales (VAS) - Anxious - 230 Minutes	230 minutes	visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)
Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline	Baseline	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes	15 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes	80 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes	110 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline	Baseline	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes	15 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes	80 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes	110 minutes	Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)
Pegboard Task - Baseline (Dominant Hand)	Baseline	The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds
Pegboard Task - 15 Minutes (Dominant Hand)	15 minutes	The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds
Pegboard Task - Baseline (Non-Dominant Hand)	Baseline	The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds.
Pegboard Task - 15 Minutes (Non-Dominant Hand)	15 minutes	The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds.
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes	110 minutes	Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)
Hopkins Verbal Learning Task (HVLT) - Delayed Recall	45 minutes	Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function with word recall at 30 minutes) (0 no words recalled - 12 all words recalled)
Verbal Fluency	15 minutes	Verbal Fluency Task: requires subjects to generate as many words as possible beginning with a single letter (e.g., H) during a one-minute interval. (total words in one-minute interval)
Hopkins Verbal Learning Task (HVLT) - Total Recall	15 minutes	Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function based on word recall. (0 = no words recalled - 36 = all words recalled)
Number of Drinks Felt Consumed at Baseline	Baseline	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Number of Drinks Felt Consumed - 15 Minutes	15 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Number of Drinks Felt Consumed - 45 Minutes	45 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Number of Drinks Felt Consumed - 80 Minutes	80 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Number of Drinks Felt Consumed - 110 Minutes	110 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
Number of Drinks Felt Consumed - 170 Minutes	170 minutes	The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Countries

United States

Participant flow

Participants by arm

Arm	Count
Family History Negative for Alcoholism Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives.	49
Family History Positive for Alcoholism Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by COGA.	24
Total	73

Withdrawals & dropouts

Period	Reason	FG000	FG001
Overall Study	didn't like the medication	1	1
Overall Study	Physician Decision	1	0
Overall Study	Thiopental not available	3	0
Overall Study	Withdrawal by Subject	4	1

Baseline characteristics

Characteristic	Total	Family History Negative for Alcoholism	Family History Positive for Alcoholism
Age, Categorical <=18 years	0 Participants	0 Participants	0 Participants
Age, Categorical >=65 years	0 Participants	0 Participants	0 Participants
Age, Categorical Between 18 and 65 years	73 Participants	49 Participants	24 Participants
Age, Continuous	24.22 years STANDARD_DEVIATION 2.69	24.02 years STANDARD_DEVIATION 2.5	24.63 years STANDARD_DEVIATION 3.06
Region of Enrollment United States	73 participants	49 participants	24 participants
Sex: Female, Male Female	35 Participants	25 Participants	10 Participants
Sex: Female, Male Male	38 Participants	24 Participants	14 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk
deaths Total, all-cause mortality	— / —	— / —
other Total, other adverse events	0 / 49	0 / 24
serious Total, serious adverse events	0 / 49	0 / 24

Outcome results

Primary

Visual Analog Scales of Similarity to Alcohol - 110 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 110 Minutes	Thiopental	0.35 units on a scale	Standard Deviation 0.92
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 110 Minutes	Placebo	0.11 units on a scale	Standard Deviation 0.74
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 110 Minutes	Thiopental	0.22 units on a scale	Standard Deviation 0.85
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Primary

Visual Analog Scales of Similarity to Alcohol - 15 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 15 Minutes	Thiopental	3.23 units on a scale	Standard Deviation 2.08
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 15 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 15 Minutes	Thiopental	2.35 units on a scale	Standard Deviation 1.9
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 15 Minutes	Placebo	0.17 units on a scale	Standard Deviation 0.65

Primary

Visual Analog Scales of Similarity to Alcohol - 170 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 170 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 170 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Primary

Visual Analog Scales of Similarity to Alcohol - 230 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Primary

Visual Analog Scales of Similarity to Alcohol - 45 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 45 Minutes	Thiopental	2.91 units on a scale	Standard Deviation 1.97
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 45 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 45 Minutes	Thiopental	1.87 units on a scale	Standard Deviation 1.71
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 45 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Primary

Visual Analog Scales of Similarity to Alcohol - 80 Minutes

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 80 Minutes	Thiopental	0.84 units on a scale	Standard Deviation 1.33
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - 80 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 80 Minutes	Thiopental	0.50 units on a scale	Standard Deviation 0.74
Family History Positive	Visual Analog Scales of Similarity to Alcohol - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Primary

Visual Analog Scales of Similarity to Alcohol - Baseline

Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales of Similarity to Alcohol - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales of Similarity to Alcohol - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales of Similarity to Alcohol - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes	Thiopental	2.37 units on a scale	Standard Deviation 4.34
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes	Placebo	0.63 units on a scale	Standard Deviation 1.88
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes	Thiopental	1.61 units on a scale	Standard Deviation 4.33
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes	Placebo	0.78 units on a scale	Standard Deviation 2.59

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes	Thiopental	16.07 units on a scale	Standard Deviation 17.75
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes	Placebo	1.41 units on a scale	Standard Deviation 3.29
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes	Thiopental	6.74 units on a scale	Standard Deviation 8.3
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes	Placebo	2.04 units on a scale	Standard Deviation 6.87

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes	Thiopental	0.83 units on a scale	Standard Deviation 1.87
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes	Placebo	0.26 units on a scale	Standard Deviation 0.74
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes	Thiopental	0.52 units on a scale	Standard Deviation 1.9
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes	Placebo	0.44 units on a scale	Standard Deviation 1.16

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes	Thiopental	0.45 units on a scale	Standard Deviation 1.33
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes	Placebo	0.15 units on a scale	Standard Deviation 0.52
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes	Thiopental	0.22 units on a scale	Standard Deviation 0.85
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes	Placebo	0.26 units on a scale	Standard Deviation 0.75

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes	Thiopental	15.83 units on a scale	Standard Deviation 13.79
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes	Placebo	1.70 units on a scale	Standard Deviation 4.61
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes	Thiopental	9.30 units on a scale	Standard Deviation 12.1
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes	Placebo	1.17 units on a scale	Standard Deviation 3.94

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes	Thiopental	7.98 units on a scale	Standard Deviation 10.34
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes	Placebo	0.94 units on a scale	Standard Deviation 2.27
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes	Thiopental	3.48 units on a scale	Standard Deviation 6.07
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes	Placebo	0.74 units on a scale	Standard Deviation 2.34

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline

Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline	Thiopental	1.49 units on a scale	Standard Deviation 2.55
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline	Placebo	1.20 units on a scale	Standard Deviation 2.52
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline	Thiopental	0.48 units on a scale	Standard Deviation 0.95
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline	Placebo	0.44 units on a scale	Standard Deviation 1.31

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes	Thiopental	1.12 units on a scale	Standard Deviation 2.22
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes	Placebo	1.44 units on a scale	Standard Deviation 4.38
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes	Thiopental	1.52 units on a scale	Standard Deviation 3.94
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes	Placebo	1.91 units on a scale	Standard Deviation 4.8

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes	Thiopental	5.26 units on a scale	Standard Deviation 9.38
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes	Placebo	1.5 units on a scale	Standard Deviation 3.97
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes	Thiopental	3.87 units on a scale	Standard Deviation 6.24
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes	Placebo	1.87 units on a scale	Standard Deviation 4.46

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes	Thiopental	0.98 units on a scale	Standard Deviation 2.33
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes	Placebo	1.85 units on a scale	Standard Deviation 6.16
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes	Thiopental	1.39 units on a scale	Standard Deviation 3.73
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes	Placebo	1.65 units on a scale	Standard Deviation 4

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes	Thiopental	1 units on a scale	Standard Deviation 2.01
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes	Placebo	1.72 units on a scale	Standard Deviation 4.7
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes	Thiopental	2.30 units on a scale	Standard Deviation 6.32
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes	Placebo	2.04 units on a scale	Standard Deviation 5.17

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes	Thiopental	2.33 units on a scale	Standard Deviation 4.07
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes	Placebo	1.13 units on a scale	Standard Deviation 3.21
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes	Thiopental	2.70 units on a scale	Standard Deviation 4.99
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes	Placebo	1.57 units on a scale	Standard Deviation 3.72

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes	Thiopental	1.37 units on a scale	Standard Deviation 2.82
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes	Placebo	1.5 units on a scale	Standard Deviation 4.21
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes	Thiopental	1.78 units on a scale	Standard Deviation 4.38
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes	Placebo	1.35 units on a scale	Standard Deviation 3.33

Secondary

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline

Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline	Thiopental	1.86 units on a scale	Standard Deviation 4.41
Family History Negative for Alcoholism	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline	Placebo	2.74 units on a scale	Standard Deviation 7.16
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline	Thiopental	1.22 units on a scale	Standard Deviation 3.67
Family History Positive	Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline	Placebo	1.91 units on a scale	Standard Deviation 5.73

Secondary

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes

Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes	Thiopental	0.21 units on a scale	Standard Deviation 0.67
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes	Thiopental	0.17 units on a scale	Standard Deviation 0.49
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes	Thiopental	1.43 units on a scale	Standard Deviation 2.39
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes	Thiopental	1.04 units on a scale	Standard Deviation 1.72
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes	Thiopental	0.68 units on a scale	Standard Deviation 1.54
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes	Thiopental	0.35 units on a scale	Standard Deviation 0.65
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes	Placebo	0.09 units on a scale	Standard Deviation 0.42

Secondary

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes	Thiopental	0.43 units on a scale	Standard Deviation 1.59
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes	Thiopental	0.22 units on a scale	Standard Deviation 0.42
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes	Thiopental	2.57 units on a scale	Standard Deviation 3.35
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes	Thiopental	1.74 units on a scale	Standard Deviation 1.79
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes	Thiopental	0.73 units on a scale	Standard Deviation 1.58
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes	Thiopental	0.83 units on a scale	Standard Deviation 1.56
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Hopkins Verbal Learning Task (HVLT) - Delayed Recall

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function with word recall at 30 minutes) (0 no words recalled - 12 all words recalled)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Hopkins Verbal Learning Task (HVLT) - Delayed Recall	Thiopental	8.29 words recalled	Standard Deviation 3.39
Family History Negative for Alcoholism	Hopkins Verbal Learning Task (HVLT) - Delayed Recall	Placebo	10.44 words recalled	Standard Deviation 1.75
Family History Positive	Hopkins Verbal Learning Task (HVLT) - Delayed Recall	Thiopental	8.74 words recalled	Standard Deviation 3.24
Family History Positive	Hopkins Verbal Learning Task (HVLT) - Delayed Recall	Placebo	10.04 words recalled	Standard Deviation 2.08

Secondary

Hopkins Verbal Learning Task (HVLT) - Total Recall

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function based on word recall. (0 = no words recalled - 36 = all words recalled)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Hopkins Verbal Learning Task (HVLT) - Total Recall	Thiopental	25.88 words recalled	Standard Deviation 6.14
Family History Negative for Alcoholism	Hopkins Verbal Learning Task (HVLT) - Total Recall	Placebo	29.02 words recalled	Standard Deviation 3.94
Family History Positive	Hopkins Verbal Learning Task (HVLT) - Total Recall	Thiopental	26.96 words recalled	Standard Deviation 4.41
Family History Positive	Hopkins Verbal Learning Task (HVLT) - Total Recall	Placebo	29.35 words recalled	Standard Deviation 3.8

Secondary

Number of Drinks Felt Consumed - 110 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 110 Minutes	Thiopental	0.35 number of drinks felt consumed	Standard Deviation 0.92
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 110 Minutes	Placebo	0.04 number of drinks felt consumed	Standard Deviation 0.3
Family History Positive	Number of Drinks Felt Consumed - 110 Minutes	Thiopental	0.22 number of drinks felt consumed	Standard Deviation 0.6
Family History Positive	Number of Drinks Felt Consumed - 110 Minutes	Placebo	0 number of drinks felt consumed	Standard Deviation 0

Secondary

Number of Drinks Felt Consumed - 15 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 15 Minutes	Thiopental	3.28 number of drinks felt consumed	Standard Deviation 2.1
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 15 Minutes	Placebo	0.11 number of drinks felt consumed	Standard Deviation 0.43
Family History Positive	Number of Drinks Felt Consumed - 15 Minutes	Thiopental	3.22 number of drinks felt consumed	Standard Deviation 2.63
Family History Positive	Number of Drinks Felt Consumed - 15 Minutes	Placebo	0.17 number of drinks felt consumed	Standard Deviation 0.49

Secondary

Number of Drinks Felt Consumed - 170 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 170 Minutes	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 170 Minutes	Placebo	0.02 number of drinks felt consumed	Standard Deviation 0.15
Family History Positive	Number of Drinks Felt Consumed - 170 Minutes	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Positive	Number of Drinks Felt Consumed - 170 Minutes	Placebo	0 number of drinks felt consumed	Standard Deviation 0

Secondary

Number of Drinks Felt Consumed - 230 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 230 Minutes	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 230 Minutes	Placebo	0 number of drinks felt consumed	Standard Deviation 0
Family History Positive	Number of Drinks Felt Consumed - 230 Minutes	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Positive	Number of Drinks Felt Consumed - 230 Minutes	Placebo	0 number of drinks felt consumed	Standard Deviation 0

Secondary

Number of Drinks Felt Consumed - 45 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 45 Minutes	Thiopental	3 number of drinks felt consumed	Standard Deviation 2
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 45 Minutes	Placebo	0.03 number of drinks felt consumed	Standard Deviation 0.16
Family History Positive	Number of Drinks Felt Consumed - 45 Minutes	Thiopental	2.91 number of drinks felt consumed	Standard Deviation 2.67
Family History Positive	Number of Drinks Felt Consumed - 45 Minutes	Placebo	0.04 number of drinks felt consumed	Standard Deviation 0.21

Secondary

Number of Drinks Felt Consumed - 80 Minutes

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 80 Minutes	Thiopental	1.14 number of drinks felt consumed	Standard Deviation 1.78
Family History Negative for Alcoholism	Number of Drinks Felt Consumed - 80 Minutes	Placebo	0.04 number of drinks felt consumed	Standard Deviation 0.3
Family History Positive	Number of Drinks Felt Consumed - 80 Minutes	Thiopental	0.96 number of drinks felt consumed	Standard Deviation 1.15
Family History Positive	Number of Drinks Felt Consumed - 80 Minutes	Placebo	0 number of drinks felt consumed	Standard Deviation 0

Secondary

Number of Drinks Felt Consumed at Baseline

The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Number of Drinks Felt Consumed at Baseline	Placebo	0 number of drinks felt consumed	Standard Deviation 0
Family History Negative for Alcoholism	Number of Drinks Felt Consumed at Baseline	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Positive	Number of Drinks Felt Consumed at Baseline	Thiopental	0 number of drinks felt consumed	Standard Deviation 0
Family History Positive	Number of Drinks Felt Consumed at Baseline	Placebo	0 number of drinks felt consumed	Standard Deviation 0

Secondary

Pegboard Task - 15 Minutes (Dominant Hand)

The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Pegboard Task - 15 Minutes (Dominant Hand)	Thiopental	84.56 seconds	Standard Deviation 22.92
Family History Negative for Alcoholism	Pegboard Task - 15 Minutes (Dominant Hand)	Placebo	65.11 seconds	Standard Deviation 10.04
Family History Positive	Pegboard Task - 15 Minutes (Dominant Hand)	Thiopental	82.04 seconds	Standard Deviation 16.36
Family History Positive	Pegboard Task - 15 Minutes (Dominant Hand)	Placebo	69.61 seconds	Standard Deviation 13.68

Secondary

Pegboard Task - 15 Minutes (Non-Dominant Hand)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Pegboard Task - 15 Minutes (Non-Dominant Hand)	Thiopental	91.19 seconds	Standard Deviation 23.23
Family History Negative for Alcoholism	Pegboard Task - 15 Minutes (Non-Dominant Hand)	Placebo	71.13 seconds	Standard Deviation 12.57
Family History Positive	Pegboard Task - 15 Minutes (Non-Dominant Hand)	Thiopental	87.09 seconds	Standard Deviation 19.99
Family History Positive	Pegboard Task - 15 Minutes (Non-Dominant Hand)	Placebo	75.48 seconds	Standard Deviation 13.74

Secondary

Pegboard Task - Baseline (Dominant Hand)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Pegboard Task - Baseline (Dominant Hand)	Thiopental	58.49 seconds	Standard Deviation 9.39
Family History Negative for Alcoholism	Pegboard Task - Baseline (Dominant Hand)	Placebo	57.37 seconds	Standard Deviation 6.84
Family History Positive	Pegboard Task - Baseline (Dominant Hand)	Thiopental	60.57 seconds	Standard Deviation 10.56
Family History Positive	Pegboard Task - Baseline (Dominant Hand)	Placebo	60.78 seconds	Standard Deviation 7.59

Secondary

Pegboard Task - Baseline (Non-Dominant Hand)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Pegboard Task - Baseline (Non-Dominant Hand)	Thiopental	64.19 seconds	Standard Deviation 10.15
Family History Negative for Alcoholism	Pegboard Task - Baseline (Non-Dominant Hand)	Placebo	62.98 seconds	Standard Deviation 8.29
Family History Positive	Pegboard Task - Baseline (Non-Dominant Hand)	Thiopental	66.52 seconds	Standard Deviation 10.95
Family History Positive	Pegboard Task - Baseline (Non-Dominant Hand)	Placebo	69.83 seconds	Standard Deviation 13.21

Secondary

Verbal Fluency

Verbal Fluency Task: requires subjects to generate as many words as possible beginning with a single letter (e.g., H) during a one-minute interval. (total words in one-minute interval)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Verbal Fluency	Thiopental	13.47 number of words	Standard Deviation 4.11
Family History Negative for Alcoholism	Verbal Fluency	Placebo	14.35 number of words	Standard Deviation 4.42
Family History Positive	Verbal Fluency	Thiopental	13.96 number of words	Standard Deviation 3.34
Family History Positive	Verbal Fluency	Placebo	14.04 number of words	Standard Deviation 3.23

Secondary

Visual Analog Scales (VAS) - Anxious - 110 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 110 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 110 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Visual Analog Scales (VAS) - Anxious - 110 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Anxious - 15 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 15 Minutes	Thiopental	0.21 units on a scale	Standard Deviation 0.89
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 15 Minutes	Thiopental	0.22 units on a scale	Standard Deviation 0.85
Family History Positive	Visual Analog Scales (VAS) - Anxious - 15 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Anxious - 170 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 170 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales (VAS) - Anxious - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 170 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Anxious - 230 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 230 Minutes	Thiopental	0.04 units on a scale	Standard Deviation 0.21
Family History Positive	Visual Analog Scales (VAS) - Anxious - 230 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Anxious - 45 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 45 Minutes	Thiopental	0.07 units on a scale	Standard Deviation 0.34
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 45 Minutes	Thiopental	0.13 units on a scale	Standard Deviation 0.46
Family History Positive	Visual Analog Scales (VAS) - Anxious - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Anxious - 80 Minutes

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 80 Minutes	Thiopental	0.05 units on a scale	Standard Deviation 0.31
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 80 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Anxious - 80 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Anxious - Baseline

visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - Baseline	Thiopental	0.12 units on a scale	Standard Deviation 0.45
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Anxious - Baseline	Placebo	0.09 units on a scale	Standard Deviation 0.29
Family History Positive	Visual Analog Scales (VAS) - Anxious - Baseline	Thiopental	0.13 units on a scale	Standard Deviation 0.34
Family History Positive	Visual Analog Scales (VAS) - Anxious - Baseline	Placebo	0.13 units on a scale	Standard Deviation 0.34

Secondary

Visual Analog Scales (VAS) - Buzzed - 110 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 110 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 110 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 110 Minutes	Thiopental	0.13 units on a scale	Standard Deviation 0.46
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Buzzed - 15 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 15 Minutes	Thiopental	2.07 units on a scale	Standard Deviation 2.06
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 15 Minutes	Thiopental	1.65 units on a scale	Standard Deviation 1.85
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 15 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Buzzed - 170 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 170 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Buzzed - 230 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Buzzed - 45 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 45 Minutes	Thiopental	1.74 units on a scale	Standard Deviation 1.78
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 45 Minutes	Thiopental	1.26 units on a scale	Standard Deviation 1.94
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 45 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.21

Secondary

Visual Analog Scales (VAS) - Buzzed - 80 Minutes

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) .

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 80 Minutes	Thiopental	0.21 units on a scale	Standard Deviation 0.68
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - 80 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 80 Minutes	Thiopental	0.52 units on a scale	Standard Deviation 0.99
Family History Positive	Visual Analog Scales (VAS) - Buzzed - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Buzzed - Baseline

visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Buzzed - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Buzzed - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 110 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 110 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 110 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 15 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 15 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 15 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales (VAS) - Depressed - 15 Minutes	Thiopental	0.13 units on a scale	Standard Deviation 0.63
Family History Positive	Visual Analog Scales (VAS) - Depressed - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 170 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 230 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 230 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 45 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 45 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 45 Minutes	Placebo	0.04 units on a scale	Standard Deviation 0.3
Family History Positive	Visual Analog Scales (VAS) - Depressed - 45 Minutes	Thiopental	0.09 units on a scale	Standard Deviation 0.42
Family History Positive	Visual Analog Scales (VAS) - Depressed - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - 80 Minutes

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 80 Minutes	Thiopental	0.02 units on a scale	Standard Deviation 0.15
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - 80 Minutes	Thiopental	0.04 units on a scale	Standard Deviation 0.21
Family History Positive	Visual Analog Scales (VAS) - Depressed - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Depressed - Baseline

visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - Baseline	Thiopental	0.07 units on a scale	Standard Deviation 0.34
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Depressed - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - Depressed - Baseline	Thiopental	0.04 units on a scale	Standard Deviation 0.21
Family History Positive	Visual Analog Scales (VAS) - Depressed - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - Drowsy - 110 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 110 Minutes	Thiopental	1.19 units on a scale	Standard Deviation 1.64
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 110 Minutes	Placebo	0.13 units on a scale	Standard Deviation 0.4
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 110 Minutes	Thiopental	1.13 units on a scale	Standard Deviation 1.25
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 110 Minutes	Placebo	0.30 units on a scale	Standard Deviation 0.7

Secondary

Visual Analog Scales (VAS) - Drowsy - 15 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 15 Minutes	Thiopental	2.86 units on a scale	Standard Deviation 2.48
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 15 Minutes	Placebo	0.39 units on a scale	Standard Deviation 0.71
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 15 Minutes	Thiopental	1.74 units on a scale	Standard Deviation 1.86
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 15 Minutes	Placebo	0.35 units on a scale	Standard Deviation 0.57

Secondary

Visual Analog Scales (VAS) - Drowsy - 170 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 170 Minutes	Thiopental	0.38 units on a scale	Standard Deviation 0.66
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 170 Minutes	Placebo	0.15 units on a scale	Standard Deviation 0.56
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 170 Minutes	Thiopental	0.26 units on a scale	Standard Deviation 0.54
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 170 Minutes	Placebo	0.22 units on a scale	Standard Deviation 0.6

Secondary

Visual Analog Scales (VAS) - Drowsy - 230 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 230 Minutes	Thiopental	0.31 units on a scale	Standard Deviation 0.6
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 230 Minutes	Placebo	0.11 units on a scale	Standard Deviation 0.43
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 230 Minutes	Thiopental	0.13 units on a scale	Standard Deviation 0.34
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 230 Minutes	Placebo	0.17 units on a scale	Standard Deviation 0.58

Secondary

Visual Analog Scales (VAS) - Drowsy - 45 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) .

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 45 Minutes	Thiopental	3.02 units on a scale	Standard Deviation 2.44
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 45 Minutes	Placebo	0.44 units on a scale	Standard Deviation 0.91
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 45 Minutes	Thiopental	2.74 units on a scale	Standard Deviation 2.01
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 45 Minutes	Placebo	0.39 units on a scale	Standard Deviation 0.58

Secondary

Visual Analog Scales (VAS) - Drowsy - 80 Minutes

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 80 Minutes	Thiopental	2.14 units on a scale	Standard Deviation 1.82
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - 80 Minutes	Placebo	0.20 units on a scale	Standard Deviation 0.45
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 80 Minutes	Thiopental	1.48 units on a scale	Standard Deviation 1.59
Family History Positive	Visual Analog Scales (VAS) - Drowsy - 80 Minutes	Placebo	0.35 units on a scale	Standard Deviation 0.78

Secondary

Visual Analog Scales (VAS) - Drowsy - Baseline

visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - Baseline	Thiopental	0.61 units on a scale	Standard Deviation 1.05
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - Drowsy - Baseline	Placebo	0.22 units on a scale	Standard Deviation 0.51
Family History Positive	Visual Analog Scales (VAS) - Drowsy - Baseline	Thiopental	0.52 units on a scale	Standard Deviation 1.04
Family History Positive	Visual Analog Scales (VAS) - Drowsy - Baseline	Placebo	0.48 units on a scale	Standard Deviation 1.31

Secondary

Visual Analog Scales (VAS) - High - 110 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 110 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 110 Minutes	Thiopental	0.14 units on a scale	Standard Deviation 0.64
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 110 Minutes	Thiopental	0.13 units on a scale	Standard Deviation 0.46
Family History Positive	Visual Analog Scales (VAS) - High - 110 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - 15 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 15 minutes

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 15 Minutes	Thiopental	2.35 units on a scale	Standard Deviation 2.25
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 15 Minutes	Thiopental	1.74 units on a scale	Standard Deviation 1.66
Family History Positive	Visual Analog Scales (VAS) - High - 15 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - 170 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 170 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 170 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 170 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - 230 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 230 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 230 Minutes	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 230 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - 45 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 45 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 45 Minutes	Thiopental	1.69 units on a scale	Standard Deviation 1.8
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - 45 Minutes	Thiopental	1.26 units on a scale	Standard Deviation 2.03
Family History Positive	Visual Analog Scales (VAS) - High - 45 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - 80 Minutes

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: 80 minutes

Population: All available data was utilized in the analysis using mixed models

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 80 Minutes	Thiopental	0.40 units on a scale	Standard Deviation 1
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - 80 Minutes	Placebo	0.02 units on a scale	Standard Deviation 0.15
Family History Positive	Visual Analog Scales (VAS) - High - 80 Minutes	Thiopental	0.61 units on a scale	Standard Deviation 1.08
Family History Positive	Visual Analog Scales (VAS) - High - 80 Minutes	Placebo	0 units on a scale	Standard Deviation 0

Secondary

Visual Analog Scales (VAS) - High - Baseline

visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High)

Time frame: Baseline

Population: All available data was utilized in the analysis using mixed models.

Arm	Measure	Group	Value (MEAN)	Dispersion
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Negative for Alcoholism	Visual Analog Scales (VAS) - High - Baseline	Placebo	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - Baseline	Thiopental	0 units on a scale	Standard Deviation 0
Family History Positive	Visual Analog Scales (VAS) - High - Baseline	Placebo	0 units on a scale	Standard Deviation 0

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

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Visual Analog Scales of Similarity to Alcohol - 110 Minutes

Visual Analog Scales of Similarity to Alcohol - 15 Minutes

Visual Analog Scales of Similarity to Alcohol - 170 Minutes

Visual Analog Scales of Similarity to Alcohol - 230 Minutes

Visual Analog Scales of Similarity to Alcohol - 45 Minutes

Visual Analog Scales of Similarity to Alcohol - 80 Minutes

Visual Analog Scales of Similarity to Alcohol - Baseline

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes

Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes

Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes

Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes

Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline

Hopkins Verbal Learning Task (HVLT) - Delayed Recall

Hopkins Verbal Learning Task (HVLT) - Total Recall

Number of Drinks Felt Consumed - 110 Minutes

Number of Drinks Felt Consumed - 15 Minutes

Number of Drinks Felt Consumed - 170 Minutes

Number of Drinks Felt Consumed - 230 Minutes

Number of Drinks Felt Consumed - 45 Minutes

Number of Drinks Felt Consumed - 80 Minutes

Number of Drinks Felt Consumed at Baseline

Pegboard Task - 15 Minutes (Dominant Hand)

Pegboard Task - 15 Minutes (Non-Dominant Hand)

Pegboard Task - Baseline (Dominant Hand)

Pegboard Task - Baseline (Non-Dominant Hand)

Verbal Fluency

Visual Analog Scales (VAS) - Anxious - 110 Minutes

Visual Analog Scales (VAS) - Anxious - 15 Minutes

Visual Analog Scales (VAS) - Anxious - 170 Minutes

Visual Analog Scales (VAS) - Anxious - 230 Minutes

Visual Analog Scales (VAS) - Anxious - 45 Minutes

Visual Analog Scales (VAS) - Anxious - 80 Minutes

Visual Analog Scales (VAS) - Anxious - Baseline

Visual Analog Scales (VAS) - Buzzed - 110 Minutes

Visual Analog Scales (VAS) - Buzzed - 15 Minutes

Visual Analog Scales (VAS) - Buzzed - 170 Minutes

Visual Analog Scales (VAS) - Buzzed - 230 Minutes

Visual Analog Scales (VAS) - Buzzed - 45 Minutes

Visual Analog Scales (VAS) - Buzzed - 80 Minutes

Visual Analog Scales (VAS) - Buzzed - Baseline

Visual Analog Scales (VAS) - Depressed - 110 Minutes