BLYS and IFN in SLE

BLyS and IFN Responses to Antigen Challenge in Human SLE

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00611611

Enrollment

Registered

2008-02-11

Start date

2007-10-31

Completion date

2009-04-30

Last updated

2011-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic Lupus Erythematosus

Brief summary

This protocol tests whether changes in BLyS or IFN can be detected in a normal immune response to a vaccine and, if so, whether the response differs between those with lupus and healthy controls.

Interventions

BIOLOGICALfluzone

once

BIOLOGICALpneumovax

once

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* ACR lupus criteria * 18\<age\<65

Exclusion criteria

* chronic infection or cancer * pregnancy

Design outcomes

Primary

Measure	Time frame
change in specific antibodies in response to vaccine	2 weeks

Secondary

Measure	Time frame
change in BLyS after vaccination	2 weeks
change in IFN after vaccination	2 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026