Viral Laryngitis, Viral Tracheitis
Conditions
Keywords
Viral laryngitis;, Viral tracheitis;, Herbal medicine;, Traditional medicine;, Aromatic essential oils;
Brief summary
This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute viral Laryngitis or Tracheitis. Study objectives: Primary to demonstrate a hoarseness or cough relief within 20 minutes after first administration of treatment with the spray. Secondary to demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment
Detailed description
This study compared the efficacy of spray containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, against placebo in the treatment of patients with acute viral Laryngitis or Tracheitis. In- vitro and clinical studies suggest therapeutic potential of aromatic herbs and trees oils in the treatment of Laryngitis or Tracheitis. The pharmacological and clinical activity of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, include anti-inflammatory, anti-bacterial and anti-viral activities. Some of these herbs and trees oils have direct activity on the respiratory tract, the coughing reflex and the airflow in the nasal tract.
Interventions
DIETARY_SUPPLEMENTmixture of aromatic essential oils.
3% of mixture containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, spraying to the larynx.
DIETARY_SUPPLEMENTplacebo
0.1% of Lemon VIP (Florasynth,Israel), spraying to the larynx.
Sponsors
HaEmek Medical Center, Israel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of acute viral Laryngitis or viral tracheitis. * Active disease less than 48 hours * Patients agree to sign informed consent according to GCP and Israel national regulations.
Exclusion criteria
* Acute lower respiratory tract infection. * C.O.P.D.(Chronic Obstructive Pulmonary Disease) * Under any antibiotically treatment. * Asthma disease. * Under coumadine therapy. * Hyper sensitivity to Aromatic essential oils. * Any immuno-suppressive disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To demonstrate a cough or hoarseness relief within the first 20 minutes after first administration of treatment with the spray. | 20 minutes |
Secondary
| Measure | Time frame |
|---|---|
| To demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment. | 3 days |
Countries
Israel
Outcome results
None listed