Alzheimer's Disease
Conditions
Keywords
Alzheimer's disease, Cognitive training
Brief summary
The purpose of this study is to see if an intense two-week long cognitive training program helps the thinking ability of adults with very mild Alzheimer Disease. We anticipate that scores on clinical cognitive tests will be better after the training.
Detailed description
Twenty of the 30 subjects will be recruited to participate in functional magnetic resonance imaging (fMRI). Scanning will be done while subjects perform a verbal learning task. Ten subjects will be scanned before and after the two week training. Another ten will be scanned twice at a two week interval before beginning the cognitive training.
Interventions
BEHAVIORALCognitive Training
Intense cognitive training, two consecutive weeks, each weekday, 6 hours/day
Sponsors
Alzheimer's Association
University of Kansas
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of very mild Alzheimer's Disease (CDC of 0.5) and mild Alzheimer's Disease (CDC of 1.0)
Exclusion criteria
* Neurologic disorder other than Alzheimer's disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite score of 5 cognitive tests including 1)WAIS digit span, 2) word fluency, 3) trail making test-A 4) Rey Osterrieth complex figure and 5) MMSE | 2 weeks with FU at 2 and 4 months |
Secondary
| Measure | Time frame |
|---|---|
| Brain activity during functional brain imaging | 2 weeks |
Countries
United States
Outcome results
None listed