Acute Myocardial Infarction
Conditions
Keywords
Angioplasty, Transluminal, Percutaneous Coronary, tirofiban, Magnetic Resonance Imaging, Myocardial Infarction
Brief summary
The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.
Interventions
DRUGtirofiban
tirofiban (25 μg/kg bolus and 0.15 μg/kg/min maintenance infusion for 24 hours)
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset * ST-segment elevation more than 1 mm in two or more contiguous leads or presumably a new-onset left bundle branch blockage
Exclusion criteria
* hemodynamic instability * history of MI * old age \> 80years * Patients with bleeding diathesis (coagulopathy, thrombocytopenia or platelet dysfunction, Gastrointestinal or genitourinary bleeding within the prior 3 months)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size and its transmural extent using MRI | within the first 30 days after index procedure |
Secondary
| Measure | Time frame |
|---|---|
| pre-PCI thrombolysis in myocardial infarction grade, post-PCI myocardial blush grade, ST-segment resolution on electrocardiography, and left ventricular ejection fraction on echocardiography | at 6 month after index procedure |
Outcome results
None listed