Prostate Lesions
Conditions
Brief summary
The goal is to develop MR imaging techniques to improve delineation of cancer extent, and to improve differential diagnosis between prostate cancer and benign prostate hyperplasia or other benign diseases.
Interventions
DEVICEmagnetic resonance imaging
MR contrast agent (0.1 mmol/kg)
Sponsors
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. A male older than 21 years of age and under age of 80, 2. Either a normal healthy volunteer; a patient who has confirmed prostate cancer and decided to receive prostatectomy; or a patient who has persistent elevated PSA higher than 4.0 ng/ml, and with a prior benign biopsy scheduled to receive the second biopsy.
Exclusion criteria
1. Unwilling to give informed consent, 2. Have implanted prosthetic heart valves, pacemaker, neuro-stimulation devices, surgical clips (hemostatic clips) or other metallic implants, 3. Have engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or have imbedded metal fragments from military activities, 4. Have received orthodontic work involving ferromagnetic materials, 5. Claustrophobic, 6. Unable to lie down still for 60 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To demonstrate that multi-voxel MR spectroscopy and diffusion tensor imaging can accurately diagnose prostate cancer and benign diseases, also to provide an accurate disease extent. | at completion of the study |
Countries
United States
Outcome results
None listed