Angioplasty, Transluminal, Percutaneous Coronary
Conditions
Keywords
Myocardial infarct size, Atorvastatin, SPECT, Hydroxymethylglutaryl-CoA Reductase Inhibitors
Brief summary
The purpose of this study to determine whether statin pretreatment decrease myocardial infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
Interventions
DRUGatorvastatin
atorvastatin 80mg/day before primary coronary intervention
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset * ST segment elevation more than 1 mm in two or more contiguous leads or presumably a new onset left bundle branch blockage
Exclusion criteria
* Cardiogenic shock * History of myocardial infarction * Chronic liver disease * Previous or current statin use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial infarct size by SPECT | between 5 and 14 days after acute myocardial infarction |
Secondary
| Measure | Time frame |
|---|---|
| Myocardial infarct size measured by contrast-enhanced MRI | within 14 days after acute myocardial infarction |
| Myocardial blush grade after the procedure | immediate after procedure |
| complete ST resolution | at 60 minutes after the procedure |
| major adverse cardiac events related to left ventricular dysfunction (death, new-onset sustained hypotension or heart failure, and hospital readmission for left ventricular dysfunction) | at 6 months after the procedure |
Countries
South Korea
Outcome results
None listed