Treatment of Acute Rhino-Sinusitis With Essential Oils of Aromatic Plants

Treatment of Acute Rhino-Sinusitis With Essential Oils of Some Aromatic Medical Plants.

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00610779

Enrollment

Registered

2008-02-08

Start date

2008-01-31

Completion date

2008-05-31

Last updated

2008-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhino-Sinusitis

Keywords

Rhino-sinusitis;, Herbal medicine;, Traditional medicine;, Aromatic essential oils;

Brief summary

This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute Rhino-sinusitis. Study objectives: Primary to demonstrate a relief in the nasal obstruction within 20 minutes after first administration of treatment with the spray. Secondary to demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment

Detailed description

This study compared the efficacy of spray containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, against placebo in the treatment of patients with acute Rhino-sinusitis. In- vitro and clinical studies suggest therapeutic potential of aromatic herbs and trees oils in the treatment of Rhino-sinusitis. The pharmacological and clinical activity of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, include anti-inflammatory, anti-bacterial and anti-viral activities. Some of these herbs and trees oils have direct activity on the respiratory tract, the coughing reflex and the airflow in the nasal tract.

Interventions

DIETARY_SUPPLEMENTmixture of aromatic essential oils.

1% of mixture containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, spraying to the nose.

DIETARY_SUPPLEMENTplacebo

0.1% of Lemon VIP (Florasynth,Israel), spraying to the nose.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of acute Rhino-sinusitis. * Active disease less than 96 hours * Patients agree to sign informed consent according to GCP and Israel national regulations.

Exclusion criteria

* Acute Sinusitis that need to get an antibiotically treatment . * Nasal polyposis. * Under any antibiotically treatment. * Asthma disease. * Under coumadine therapy. * Hyper sensitivity to Aromatic essential oils. * Any immuno-suppressive disease

Design outcomes

Primary

Measure	Time frame
To demonstrate a relief in the nasal obstruction within the first 20 minutes after first administration of treatment with the spray.	20 minutes

Secondary

Measure	Time frame
To demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment.	3 days

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026