Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00610597

Enrollment

Registered

2008-02-08

Start date

2005-01-31

Completion date

2008-01-31

Last updated

2008-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcoholic Liver Disease, Chronic Hepatitis C Virus

Keywords

liver, alcohol, lymphocyte

Brief summary

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Detailed description

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Alcohol excess intake and suspected liver disease * Alcohol excess intake and clinical liver cirrhosis * chronic hepatitis C virus infection and suspected liver disease * chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion criteria

* bacterial or fungal infection * immunosuppressive treatment * other causes of liver disease

Countries

Belgium

Outcome results