Urinary Tract Disease
Conditions
Keywords
Refractory lower urinary tract dysfunction, Sacral neuromodulation, Brain effects, Neuroimaging, Neuromodulation
Brief summary
Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood. We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).
Interventions
RADIATIONBaseline neuroimaging
Baseline neuroimaging using PET and MRI of the brain in patients before sacral neuromodulation
RADIATIONNeuroimaging during sacral neuromodulation
Neuroimaging during sacral neuromodulation using PET
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with refractory lower urinary tract dysfunction scheduled for sacral neuromodulation
Exclusion criteria
* Pregnancy * Age \<18 years * Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of sacral neuromodulation on brain activity | 2-8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Differences in brain activity effects of sacral neuromodulation (SNM) in patients with successful compared to failed SNM testing | immediately and 2-8 weeks after study inclusion |
Countries
Switzerland
Outcome results
None listed