Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00609700

Acronym

VoLTRAB

Enrollment

Registered

2008-02-07

Start date

2007-12-31

Completion date

2010-12-31

Last updated

2011-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Burn Injury

Keywords

burn injury, volume replacement, Ringer's Lactate solution, Ringer's Acetate solution, volume replacement with crystalloids

Brief summary

This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.

Detailed description

In the early period following severe burn injury volume replacement with high amounts of crystalloids is necessary. In this study we compare the organ function scores of a historical patient group, treated with Ringer's Lactate solution, with an actual patient population, treated with Ringer's Acetate solution.

Interventions

None listed

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age \>=18 years and \<80years * Burned surface area \>20% and \<70% * Burn injury \< 24 hours * Agreement to the study procedures

Exclusion criteria

* Burned surface area \> 70% * Expected survival time \< 24 hours * Acute or chronic heart failure NYHA III or IV * Adult respiratory distress syndrome * Renal failure * Hepatic failure

Design outcomes

Primary

Measure	Time frame
Change of SOFA-score from day 3 to day 7 after severe burn injury	day3, day7, day28, day60

Secondary

Measure	Time frame
Changes in electrolyte-balance	day3, day7, day28

Countries

Germany

Outcome results