Brain Imaging of Psychotherapy for Depression

Brain Imaging of Psychotherapy for Depression (Includes, Reward System Recovery Following Behavioral Activation Therapy in Depression)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00609453

Enrollment

Registered

2008-02-07

Start date

2006-10-31

Completion date

2008-01-31

Last updated

2012-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Keywords

Control participants

Brief summary

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

Interventions

BEHAVIORALBrief Behavioral Activation Treatment for Depression

Weekly individual therapy sessions

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder * For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion criteria

* A history of serious head injury or neurological disease or psychosis * Current use of psychoactive medications * Factors that could affect MRI safety including current or planned pregnancy * For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Inventory	three times over 12 weeks
Functional Magnetic Resonance Imaging	twice in 12 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026