Identification of Cardiovascular Risk Factors Linked to Renal Failure Progression

Vascular Risk Factors and Coronary Calcifications in Chronic Renal Failure Patients: Identification of Specific Factors Linked to Renal Failure Progression

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00608998

Acronym

Pre-HD

Enrollment

120

Registered

2008-02-06

Start date

2007-07-31

Completion date

2011-10-31

Last updated

2021-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Renal Failure

Keywords

Chronic renal failure, Vasculopathy, Cardiovascular risk, Chronic renal failure patients

Brief summary

The aim of this study is to appreciate the influence of renal failure progression on vasculopathy (coronary calcifications and left ventricular hypertrophy) and cardiovascular risk factors.

Detailed description

The aim of this study is to appreciate the relationship between: * extension of coronary calcifications and chronic renal failure progression * extension of coronary calcifications and levels of osteoprotegerin (bone disease marker) * cardiovascular risk factors and coronary calcifications * cardiovascular risk factors and existence of cardiovascular diseases

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patient who has signed the written consent form * Patient aged \> 18 and \< 90 years * Chronic renal failure defined by glomerular filtration rate (GFR) * group 1: GFR \>90 mL/min with urinary biological abnormalities and GFR comprised between 90 and 60 mL/min * group 2: GFR comprised between 60 and 30 mL/min * group 3: GFR \<30 mL/min but without dialysis therapy

Exclusion criteria

* Chronic renal failure patient requiring dialysis therapy

Design outcomes

Primary

Measure	Time frame
description of osteoprotegerin levels according to chronic renal failure progression	inclusion

Secondary

Measure	Time frame
calcium score description according to chronic renal failure progression	inclusion
osteoprotegerin description according to calcium score	inclusion
relationship between cardiovascular risk factors and calcium score	inclusion
relationship between cardiovascular risk factors and cardiovascular disease	inclusion

Countries

France

Outcome results