Head and Neck Cancer
Conditions
Keywords
Newly Diagnosed head and neck cancer
Brief summary
Patients with head and neck cancer and are schedule to receive standard radiation therapy known as IMRT to treat cancer
Detailed description
In this study, we will plan additional measurements of the position of the patient's organs weekly during radiation treatment. We will analyze these measurements in order to evaluate whether we need to adjust our treatment procedures for the remainder of the treatments. We might adjust the dose of radiation received to specific organs in order to try to minimize the amount of radiation the healthy tissue receives.
Interventions
RADIATIONIMRT
Sponsors
Washington University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>= 18 * Karnofsky Performance Status of \>= 60 * New diagnosis of head-and-neck cancer, all subsites included (i.e. nasopharynx, oropharynx, oral cavity, hypopharynx, larynx.) * All stages with measurable gross disease (\>= 1.0 cm) by CT imaging * Pathologic confirmation of squamous cell carcinoma by biopsy or cytology * Signed study-specific consent form * Sequential or concurrent chemotherapy is allowed but not mandated. (no chemotherapy is allowed if patient is judged not to be a candidate for chemotherapy by the medical oncologist)
Exclusion criteria
* Age \< 18 * Karnofsky Performance Status \< 60 * Radiographic or pathologic evidence of distant metastatic disease (i.e. other than cervical lymph nodes) * Prior radiation therapy to the head-and-neck region
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of adaptive radiation therapy in the definitive treatment (MLC-based IMRT or helical tomotherapy) | 7 weeks | Feasibility is determined by employing weekly 3D onboard imaging for plan re-evaluation and initiation of an adaptive process if the original PTV and/or normal structure goals are compromised. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measure additional time required by physician and ancillary staff for the process of adaptive IMRT | 7 weeks | Recording on a weekly basis the actual time required for repeat CT imaging, plan re-evaluation, replanning, and repeat physics QA. |
| Identify a subset of patients in whom adaptive IMRT would be recommended | 7 weeks | — |
| Measure acute and late toxicity | Until patient death | — |
| Local, regional, and distant recurrence | Until recurrence | — |
Countries
United States
Outcome results
None listed