Tachycardia, Postural Orthostatic Tachycardia Syndrome
Conditions
Keywords
heart rate, blood pressure, blood volume, sympathetic nervous system, orthostatic tachycardia, orthostatic intolerance, POTS
Brief summary
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.
Detailed description
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder. This is not a clinical trial in the classical sense, but an omnibus protocol to allow for disntinct and personalized pathophysiological testing.
Interventions
RADIATIONDAXOR
131-I-Human Serum Albumin Blood Volume Assessment Kit
PROCEDUREQSweat
Quantitative Sweat Testing
DRUGIntrinsic Heart Rate
Atropine 0.04 mg/kg IV in divided doses Propranolol 0.2 mg/kg IV in divided doses
Sponsors
Satish R. Raj
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Orthostatic intolerance
Exclusion criteria
* Inability or unwillingness to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physiological abnormalities in orthostatic intolerance | 1 day | varied metrics used here |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| quantitative sweat testing | 2 hours | sweat volumes after a QSweat test |
| blood volume | 1 day | Blood volume as measured by DAXOR technique |
| intrinsic heart rate | 1 hour | Heart rate after IV propranolol and IV atropine |
| residual sympathetic function after pharmacological autonomic blockade | 3 hours | changes in BP after trimethaphan infusions |
| norepinephrine spillover | 3 hours | tritiated norepunephrine spillover data |
Countries
United States
Outcome results
None listed