Bipolar I Disorder
Conditions
Brief summary
The purpose of the research is to study brain structure, function and chemistry of patients with bipolar disorder who are receiving lithium, an FDA-approved treatment for bipolar mania, in order to better understand who benefits from treatment and why they respond to medications. Studying this may help improve treatment and outcome in patients with bipolar disorder.
Interventions
DRUGlithium
600 mg - 1800 mg per day
DRUGLithium
600 - 1800 mg
Sponsors
University of Cincinnati
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
- bipolar patients (Manic=, depressed=60; 30 patients/year): 1. The patient meets DSM-IV criteria for type I bipolar disorder, manic or mixed, or depressed. 2. The patient has an index Young Mania Rating Scale (YMRS)total score \>15 or Montgomery Asberg Rating Scale (MADRS) total score \>20. 3. The patient is between 15 and 55 years old. Inclusion Criteria- Healthy subjects (N=40): 1. Healthy subjects will be between the ages of 15 and 55 years. 2. Healthy subjects will have no history of any Axis I psychiatric disorder. 3. Healthy subjects will have no first-degree relatives with affective or psychotic disorders.
Exclusion criteria
All subjects will be excluded from participation for the following reasons. 1. Any medical or neurological disorder that could influence fMRI and MRS results. 2. A history of mental retardation or an estimated IQ total score \<85. 3. An MRI scan is contraindicated in the subject for any reason, including psychological impediments to being inside the MR scanner. 4. The patient cannot attend follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The purpose of the research is to study brain structure, function and chemistry of patients with bipolar disorder who are receiving lithium. | 8 weeks |
Countries
United States
Outcome results
None listed