Contrast-Induced Nephropathy
Conditions
Keywords
Contrast-induced nephrophaty, Contrast media, Angiography, Coronary percutaneous intervention
Brief summary
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.
Interventions
DRUGSodium Bicarbonate
Patients in the sodium bicarbonate group (154 mEq/L) received 3 ml/kg for 1 hour before contrast medium, followed by an infusion of 1 ml/kg/h for 6 hours after the procedure
DRUGIsotonic Saline
Patients assigned to the isotonic saline group received 1 ml/kg/h 0.9% sodium chloride for 12 hours before and after the procedure
Sponsors
Ospedale Misericordia e Dolce
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with creatinine clearance \< 60 mL/min
Exclusion criteria
* contrast medium administration within the previous 10 days * end-stage renal failure requiring dialysis * refusal to give informed consent
Countries
Italy
Outcome results
None listed