Metabolic Disturbances in Polycystic Ovary Syndrome (PCOS)

Insulin Resistance in Polycystic Ovary Syndrome (PCOS)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00606671

Enrollment

Registered

2008-02-04

Start date

2004-02-29

Completion date

2006-05-31

Last updated

2008-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Keywords

polycystic ovary syndrome (PCOS)

Brief summary

The scope of the study was to investigate different metabolic aspects that may lead to or are a consequence of insulin resistance in premenopausal women with polycystic ovary syndrome (PCOS). We use gold standard methods for evaluation of insulin resistance. We take muscle and fat biopsies for investigation of gene expression of different cytokines associated with insulin resistance. We investigate the incretin hormones GIP and GLP-1. These two hormones play a central role in glycemic control, and diabetic subjects are known to have alterations in their incretin hormones. The incretin hormones have not previously been investigated in women with PCOS.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* Premenopausal women that meet the Rotterdam criteria for PCOS (BMI \< 40) * Age and BMI matched control women that do not have any signs or symptoms of PCOS

Exclusion criteria

* BMI \> 40. mani fest diabetes or other known diseases

Design outcomes

Primary

Measure	Time frame
insulin resistance	2004-2006

Secondary

Measure	Time frame
gene expression of cytokines in fatty tissue	2004-2006

Countries

Denmark

Outcome results