Gastric Cancer
Conditions
Keywords
Gastrectomy, Oral feeding, Nutrition, Gastric cancer
Brief summary
The aim of this study is to determine whether early oral feeding after curative resection for gastric cancer would be tolerable and give an effect on the recovery.
Detailed description
Most patients who undergo gastric resection for gastric cancer have maintained going on a fast of over three days after operation. Surgeons have believed that early oral feeding might worsen patients' condition by prolonged postoperative ileus. Therefore, patients received nothing by oral route until resolution of the ileus. However, the current trend toward minimal operative injury and early discharge from hospital. In addition, development of operative technique and instrument make the operation time to be short and the patients to be fast recovery, and thus it is possible to feed early in less than two days after operation. The aim of this study is to determine whether early oral feeding after curative resection for gastric cancer would be tolerable and give an effect on the recovery. We collect fifty-eight patients for this study and divide into two groups using randomization method. In the early feeding group, patients will receive the liquid diet two day after operation followed by soft diet postoperative three day. Meanwhile, the patients who categorized into control group will start the liquid diet postoperative four day followed by soft diet postoperative six day. We evaluate the morbidity or mortality rate and laboratory findings. Of course, it is supposed to be same in amount of fluid and calories between two groups.
Interventions
OTHERConventional feeding
Procedure of Conventional feeding group: Patients are supplied water on day 3 after operation, liquid diet on day 4 and 5 and soft diet on 6 day.
OTHEREarly oral feeding
Procedure of Early oral feeding group: Patients are supplied water on day 1 after operation, liquid diet on day 2 and soft diet on day 3 day.
Sponsors
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients who underwent gastrectomy for adenocarcinoma of stomach with following criteria: 1. Performed curative resection 2. Have The American Society of Anaesthesiologists (ASA) score of less than 3
Exclusion criteria
1. Patients who have simultaneously other cancer. 2. Patients who underwent gastric resection at past time. 3. Patients who have cancer with bleeding or perforation or obstruction. 4. Patients who have any injury to the pancreas capsule on operation. 5. Patients who get pregnancy. 6. Patients who are treating diabetics with Insulin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Days of hospital stay after operation | within 30 days after operation | We measure the length of hospital stay after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Laboratory findings after operation: Albumin, complete blood count, total cholesterol, cholinesterase and C-reactive protein are measured | 1,3,5 and 7 day after operation | — |
| Symptom of Patients: Question to patients about symptoms | before operation and 1,3,5,7 day after operation | — |
| Cost effectiveness: Total cost duration of hospitalization | within 30 days after admission | We measure total cost from admission to discharge after operation |
| Day of recovery of bowel sound and flatus: Evidence of recovery of bowel sound by physician's examination and Evidence of first flatus by question to patient | within 30 days after operation | We measure the days of flatus within 30 days after operation |
| Immunologic Outcomes : IL-1, IL-2, IL-6, IL-8, TNF-a will by measured by ELISA | before operation and 1,3,5,7 day after operation | — |
| Postoperative morbidity rate in hospital days: Clinically definite morbidity confirmed by physicians according to offered protocol | within 30 days after operation | We observe the occurrence of morbidity after operation |
| Quality of life: EORTC QLQ30, STO22 | 1,2 and 3 month after operation | — |
Countries
South Korea
Outcome results
None listed