Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma

A Randomized Double Blind Study of the Dose Response Effects of Fluticasone Propionate on Hypertonic-saline Induced Bronchoconstriction in Asthmatic Subjects

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00606242

Acronym

FluSAL

Enrollment

Registered

2008-02-01

Start date

2000-01-31

Completion date

2007-12-31

Last updated

2014-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Brief summary

This study investigates the effect of a inhaled corticosteroid (fluticasone or Flovent) on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Interventions

DRUGFluticasone

Inhaled Fluticasone, either 100 or 1000 mcg per day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of asthma

Exclusion criteria

* Habitual cigarette smoking

Design outcomes

Primary

Measure	Time frame
FEV1	Measured every 2 weeks

Secondary

Measure	Time frame
PC20 methacholine	Measured every 2 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026