Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Undifferentiated Leukemia, Biphenotypic Leukemia, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma
Conditions
Keywords
MRI
Brief summary
The purpose of this study is to learn about possible changes in brain anatomy and in thinking abilities, such as memory skills, in patients with cancer who receive treatment with chemotherapy alone or in combination with total body radiation before undergoing stem cell transplantation.
Interventions
PROCEDUREMRI and cognitive evaluation
Patients will undergo a brain MRI study and a brief neuropsychological evaluation, at the time of enrollment for controls and prior to undergoing the conditioning treatment required for the stem cell transplant for patients. A follow-up MRI and cognitive evaluation will be performed approximately 12 months after the transplant for patients.
PROCEDUREbrain MRI study and a brief neuropsychological evaluation
A brain MRI study and a brief neuropsychological evaluation will be performed at baseline (Time 1). A follow-up MRI and cognitive evaluation will be performed and about 12 months after the baseline for healthy controls
Sponsors
Weill Medical College of Cornell University
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS), Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission at the time of enrollment * Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI) and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative allogeneic HSCT * Between 18 and 70 years of age. * Are English speaking. * Have capacity to give consent. Healthy Control Inclusion Criteria: * Have no diagnosis of cancer except basal cell carcinoma * Between 18 and 70 years of age. * Are English speaking. * Have capacity to give consent
Exclusion criteria
* Patients with signs and/or symptoms of central nervous system disease as determined by their physician or by a brain MRI, either at the time of enrollment or during the study period. * With disease progression at the time of enrollment or during the study period * With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia * With a history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness * With standard contraindications to MRI examinations Healthy Control
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| assess changes in hippocampal volume & white matter integrity prospectively in adult ca pts who get treatment w/i chemotherapy alone or in combination with total body irradiation (TBI) before undergoing hematopoietic stem cell transplantation. | conclusion of the study |
Secondary
| Measure | Time frame |
|---|---|
| assess memory and executive functions prospectively in these patients. We will investigate whether there is an association between structural brain changes and cognitive performance. | conclusion of the study |
Countries
United States
Outcome results
None listed