Liver Cancer
Conditions
Keywords
Liver resection
Brief summary
The results of this study may or may not establish useful baseline data, which will help us understand how bone marrow derived adult liver stem cells behave in normal healthy adults/volunteers (the control group), and in patients undergoing liver surgery. The bone marrow is located within your bones and is the organ which is responsible to produce blood cells and stem cells. Bone marrow derived adult liver stem cells are normal cells in your bone marrow. These liver stem cells have the capacity to regenerate or in other words to rebuild the liver after liver surgery, a process called liver regeneration. These cells are very important for the liver to regrow its tissue after liver surgery. These cells are thought to be activated in times of need by the liver. Situations like liver surgery are one of these occasions when the liver will need the extra help from these stem cells. The results of this study will establish the baseline data necessary for the understanding of how to harness the ability of these stem cells in times of liver surgery. Improvements in the ability of the liver to regrow after surgery is thought to decrease complications related to liver surgery. Harnessing this unique ability of stem cells may be utilized in the future to enhance the regrowing process of liver tissue after liver surgery, called liver regeneration.
Interventions
OTHERblood drawn
Baseline levels of bone marrow derived liver stem cells from normal healthy volunteers, which will be drawn once Two 5ml blue tubes).
Sponsors
National Cancer Institute (NCI)
Memorial Sloan Kettering Cancer Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults (≥ or equal to 18 years old). * Patients scheduled for resection of 3 or more liver segments for any indication, with or without other planned procedures. Or * Normal healthy volunteers (control).
Exclusion criteria
* Chemotherapy or GCSF treatment in the preceding 4 weeks. * CHILD'S classification B or above. * Presence of active infection. * History of lymphoma or leukemia. * Normal healthy volunteers who underwent chemotherapy treatment at any stage of their life will be excluded. * Normal healthy volunteers who are under any active treatment for any active illness will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine qualitatively and quantitatively whether bone marrow derived liver associated stem cells are mobilized from the bone marrow in patients undergoing major liver resections (3 or more liver segments). | conclusion of study |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether a difference exist in the baseline levels of bone marrow derived liver associated stem cells between normal healthy subjects/ volunteers and cancer patients prior to liver surgery. | conclusion of study |
Outcome results
None listed