Effect of Nutrition on Muscle Protein Synthesis

The Effect of Carbohydrate and Protein Intake on Muscle Protein Synthesis During Endurance Exercise

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00604929

Enrollment

Registered

2008-01-30

Start date

2008-08-31

Completion date

2009-02-28

Last updated

2015-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

muscle protein synthesis, whole-body protein breakdown, nutrition

Brief summary

The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities. We hypothesize that muscle protein synthesis is higher when protein is co-ingested during exercise.

Interventions

DIETARY_SUPPLEMENTcarbohydrate and protein

The intake of carbohydrate and protein during endurance type exercise

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 28 Years

Healthy volunteers

Yes

Inclusion criteria

* recreationally endurance trained

Exclusion criteria

* BMI \> 25 kg/m2 * Not physically active

Design outcomes

Primary

Measure	Time frame
Differences in muscle protein synthesis rates between carbohydrate and carbohydrate + protein.	1 day

Secondary

Measure	Time frame
Difference in whole-body protein synthesis and breakdown between carbohydrate and carbohydrate plus protein.	1 day

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026