Adipokines, Anorexia Nervosa
Conditions
Keywords
Anorexia nervosa, Adipokines, Ghrelin, Fat mass
Brief summary
The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.
Detailed description
Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters. Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.
Interventions
None listed
Sponsors
Istanbul University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 32 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of anorexia nervosa for Group 1-3 * Constitutionally thin healthy subjects for Group 4
Exclusion criteria
* Medical or psychiatric diagnosis other than anorexia nervosa, * History of gastrointestinal disease for Group 1-3 * History of eating disorder or gastrointestinal or psychiatric disease for control group
Countries
Turkey (Türkiye)
Outcome results
None listed