Neurogenic Bladder
Conditions
Keywords
female voiding dysfunction, Tamsolusin, prazosin
Brief summary
The purpose of this study is to determine whether Tamsolusin or Prazosin are effective in the treatment of female voiding dysfunction(BOO)
Detailed description
Voiding dysfunction is not uncommon in Tabriz.About 20% of patients in female urology clinic of Tabriz university of medical sciences sufered from some degrees of voiding dysfunction (due to bladder imparement or bladder outlet obstruction).There is limited information about medical treatment of those patients. On the other hand alpha adrenergic blockers are the first choice medication in BENIGN PROSTATIC HYPERPLASIA. There is some new facts about destribution of alpha adrenergic blockers in female pelvic floor.The purpose of this study is to comparision whether Tamsolusin 0.4/daily or Prazosin 1 mg/daily are effective in the treatment of female voiding dysfunction(BOO)
Interventions
DRUGtamsolusin
0.4 mg /day
DRUGprazosin
1 mg/day
Sponsors
Tabriz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Healthy females with voiding difficulty with MFR\<12 and post void residual urine\>50cc
Exclusion criteria
* History of pelvic floor surgury during last 3 month * Any contraindication for Tamsolusin or prazosin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patient symptoms improvement(Standard questionare) | every month untile 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Urodynamics parameters improvement | three months later |
Outcome results
None listed