Lung Cancer
Conditions
Keywords
Hodgkin's disease, CT scan
Brief summary
This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.
Detailed description
\- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.
Interventions
PROCEDUREchest computed tomography scan
Once a year for three years
Sponsors
Brigham and Women's Hospital
Dana-Farber Cancer Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Intervention model description
Single arm study of low-dose Chest CT screening for long-term Hodgkin lymphoma survivors
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 5 years or longer from initial Hodgkin's disease diagnosis * Current age 18 or older * Received mediastinal irradiation and/or alkylating-agent based chemotherapy * Smoking history of 10-pack years or more, or current smoker * Pre-approval from the participant's insurance company for the CT study
Exclusion criteria
* Patients with a history of lung cancer * Currently receiving treatment for another cancer diagnosis * Known diagnosis of any metastatic cancer * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease. | 3 years | In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Low-dose CT Screening Annual low-dose chest CT screening | 39 |
| Total | 39 |
Baseline characteristics
| Characteristic | Low-dose CT Screening |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 2 Participants |
| Age, Categorical Between 18 and 65 years | 37 Participants |
| Age, Continuous | 51 years |
| Region of Enrollment United States | 39 participants |
| Sex: Female, Male Female | 16 Participants |
| Sex: Female, Male Male | 23 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 39 |
| serious Total, serious adverse events | 0 / 39 |
Outcome results
Primary
To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease.
In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded
Time frame: 3 years
Population: Enrolled patients who underwent low-dose CCT screening- number of lung cancer diagnosed
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Low-dose CT Screening | To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease. | 0 participants |