The Natural History of Geographic Atrophy Progression (GAP) Study

Conditions

Age-Related Macular Degeneration, Geographic Atrophy

Keywords

age-related macular degeneration, geographic atrophy

Brief summary

The objective of the 18-month trial is to evaluate the natural history of geographic atrophy by assessing the rate of progression of the geographic atrophic lesion over time.

Steinberg JS, Auge J, Jaffe GJ, Fleckenstein M, Holz FG, Schmitz-Valckenberg S, GAP Study Group.

2013-06-1038 citations

10.1167/iovs.12-11538

Topography of geographic atrophy in age-related macular degeneration.

Mauschitz MM, Fonseca S, Chang P, Göbel AP, Fleckenstein M, Jaffe GJ, Holz FG, Schmitz-Valckenberg S, GAP Study Group.

2012-07-2653 citations

10.1167/iovs.12-9711

Reticular drusen associated with geographic atrophy in age-related macular degeneration.

Schmitz-Valckenberg S, Alten F, Steinberg JS, Jaffe GJ, Fleckenstein M, Mukesh BN, Hohman TC, Holz FG, Geographic Atrophy Progression (GAP) Study Group.

2011-08-24137 citations

10.1167/iovs.11-7235

Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration.

Schmitz-Valckenberg S, Fleckenstein M, Göbel AP, Hohman TC, Holz FG.

2011-01-0568 citations

10.1167/iovs.10-5619

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Clinical diagnosis of geographic atrophy secondary to age-related macular degeneration with no CNV lesion.

Exclusion criteria

* Age related

Design outcomes

Primary

Measure	Time frame
GA progression rate using fundus autofluorescence	From baseline

Secondary

Measure	Time frame
GA progression rate using fundus photography	From baseline

Countries

United States

Outcome results