Brain Cancer, CNS Cancer
Conditions
Brief summary
The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.
Interventions
OTHERfMRI Scan, pre- and post language evaluation
All subjects will undergo functional MR imaging, pre- and post-surgical language evaluation, and electrocortical stimulation mapping. The brain tumor patients will undergo these procedures twice.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers. * At least 18 years of age * English as first language
Exclusion criteria
* Patients with high grade tumors * History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia), * History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease. * History of significant claustrophobic reactions. * Pregnancy * Standard contraindications to MR examinations (e.g. implanted stimulator) * Patients, who were treated prior to our first scan, will not be eligible to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify language organization prior to surgery in patients in whom a tumor invades or is directly adjacent to the expected location of one of the language centers. | conclusion of study |
Secondary
| Measure | Time frame |
|---|---|
| To assess language reorganization over time. | conclusion of study |
Countries
United States
Outcome results
None listed