Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00599118

Enrollment

1300

Registered

2008-01-23

Start date

2005-08-01

Completion date

2035-12-01

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Keywords

Atrial Fibrillation, Genetics

Brief summary

The purpose of this study is to establish a genebank repository of blood samples and data to generate information about the hereditary (genetic) basis of atrial fibrillation.

Detailed description

Blood samples and data will be collected from subjects with atrial fibrillation and normal controls. The primary aim of future research using these samples is to identify mechanisms and pathogenesis of atrial fibrillation. Through this information, we hope to identify targets for new therapies and improve knowledge and understanding of atrial fibrillation. Identification of disease genes could improve strategies that prevent progression of atrial fibrillation to more persistent disease.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

for Atrial Fibrillation group: * Male or female at least 18 years old * Subjects with a history of or current Atrial Fibrillation * Subjects able to give informed consent

Exclusion criteria

for Atrial Fibrillation group: no history of atrial fibrillation Inclusion Criteria for Controls: * Male or female at least 18 years old * Subjects with no history of Atrial Fibrillation * Subjects able to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Genetic variants associated with atrial fibrillation	Baseline	Genome-wide association study of atrial fibrillation

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORMina K Chung, MD

The Cleveland Clinic

Outcome results