Breast Lesions
Conditions
Brief summary
This study will investigate the association of angiogenesis in breast cancer measured by magnetic resonance imaging and biomarkers with long-term prognosis of patients.
Interventions
PROCEDUREmagnetic resonance imaging
MRI contrast agent, 0.1 mmol/kg
Sponsors
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient with a breast mass highly suspicious for malignancy from clinical, mammographic or sonographic examination. * The study has been explained to the patient when she is scheduled for surgery. * Healthy normal volunteers for imaging protocol optimization.
Exclusion criteria
* Pregnancy * Patients with implanted surgical clips (hemostatic clips) or other ferromagnetic material, * Patients engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or who may have imbedded metal fragments from military activities, * Patients with metallic implants, because they may cause artifacts in diagnostic images due to magnetic field distortion, * Patients with implanted prosthetic heart valves, * Patients with pacemakers, neuro-stimulation devices, * A breast mass with features of benign tumor * The patients unwilling to participate in the study or fail to sign the consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate whether breast cancer with a higher angiogenesis activity is associated with a unfavorable outcome. | 5 years from completion of enrollment |
Secondary
| Measure | Time frame |
|---|---|
| To investigate whether angiogenesis of breast cancer is associated wit lymph node status | at completion of enrollment |
Countries
United States
Outcome results
None listed