Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease

Assessment of Adrenal Functions in Patients With Autosomal Dominant Polycystic Kidney Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00598377

Enrollment

Registered

2008-01-21

Start date

2006-09-30

Completion date

2007-09-30

Last updated

2009-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autosomal Dominant Polycystic Kidney Disease

Keywords

Autosomal dominant polycystic kidney disease, Adrenal functions, Renal volume, Glomerular filtration rate, Adrenal Cortex Function Tests

Brief summary

We aimed to evaluate the hypothalamus-pituitary-adrenal axis in autosomal dominant polycystic kidney disease (ADPKD) patients. Twenty two ADPKD patients and 27 healthy subjects were enrolled.

Detailed description

CONTEXT: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and extrarenal manifestations may be observed in many organ systems. Hypothalamus-pituitary-adrenal axis in patients with ADPKD was not evaluated extensively. OBJECTIVE: We aimed to evaluate the hypothalamus-pituitary-adrenal axis in ADPKD patients. METHODS: Twenty two ADPKD patients and 27 healthy subjects were enrolled. Basal dehydroepiandrosterone-sulfate (DHEAS) levels and cortisol and dehydroepiandrosterone responses to low dose short adrenocorticotropin stimulation test were assessed. Correlation analyses of these parameters with glomerular filtration rates, renal volumes and pain characteristics in patients with ADPKD were done.

Interventions

DRUGTetracosactin

1 microgram tetracosactin, intravenous injection, once for the test

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 56 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects * Diagnosis of autosomal dominant polycystic kidney disease

Exclusion criteria

* A glomerular filtration rate below 60 ml/min * History of recent major surgery * Systemic infections with fever * Significant hirsutism (Ferriman Gallwey score≥8) * Congenital adrenal hyperplasia * Late onset congenital adrenal hyperplasia * Systemic corticosteroid use (including previous use) * Topical corticosteroid use * Menstrual irregularity * History of thromboembolism * Uncontrolled diabetes or hypertension * History of psychosis * Pregnancy * Lactation * History of hypersensitivity to tetracosactin

Design outcomes

Primary

Measure	Time frame
Inadequate response to tetracosactin infusion	30 and 60 minutes after the drug is administered

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026