Depression, Intracranial Pressure
Conditions
Keywords
depression, electroconvulsive therapy, Ultrasonography Doppler Transcranial, intracranial pressure
Brief summary
The purpose of this study is to determine whether electroconvulsive therapy (ECT) has an influence on pressure within the human brain before, during and after ECT.
Detailed description
1. Aim: 1. Our main objective concerning this study is to determine to what extent ECT does lead to an increase of the Pulsatility Index (as an indicator of intracerebral pressure) measured by a Transcranial Doppler Device (TCD). 2. As a secondary objective we want to compare the PI measurements with simultaneously measured systemic blood pressure. 2. Study design: a.Observational study: cohort study 3. Treatment: a. Treatment as usual, PI and blood pressure measurement at baseline, just before ECT, during and 5 minutes after ECT. Data will be collected during unilateral treatment during 3 consecutive ECT treatments. 4. Endpoints: 1. A minimum of sixteen patients are needed according to the power analysis.
Interventions
None listed
Sponsors
Rijnstate Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Temporal window to measure PI * Major depression * Psychotic depression
Exclusion criteria
* Under 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulsatility Index before, during and after electroconvulsive therapy | before, during and after three consecutive ECT treatments |
Secondary
| Measure | Time frame |
|---|---|
| Bloodpressure before, during and after ECT. | before, during and after three consecutive ECT treatments. |
Countries
Netherlands
Outcome results
None listed