Rheumatoid Arthritis
Conditions
Keywords
rheumatoid arthritis, African Americans, osteopenia, osteoporosis, bone mineral density
Brief summary
The objective of the proposed study is to assess bone health and determinants of bone health among select subpopulations of rheumatoid arthritis patients.
Detailed description
The overall hypothesis of this study is that osteopenia and/or osteoporosis are common among African Americans and men with rheumatoid arthritis and there are identifiable genetic and environmental factors contributing to the pathogenesis of bone loss in these groups. The Specific Aims of the study are to: 1. Determine baseline hip and lumbar spine bone density (BMD) values and osteopenia/osteoporosis prevalence among African American men and women with early RA and among male veterans with established RA. 2. Identify environmental factors and candidate alleles, which confer increased risk of reduced baseline BMD loss over time among African American men and women with early RA and among male veterans with established RA.
Interventions
None listed
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
University of Nebraska
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of rheumatoid arthritis per ACR guidelines
Exclusion criteria
* Patients with diagnosis \> 2yrs (CLEAR study)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone mineral density | baseline and at 5 years disease | Bone mineral density (BMD) test measures calcium and other minerals in bone. Bones containing more minerals are denser, so they tend to be stronger and less likely to break. |
Countries
United States
Outcome results
None listed