Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure

Use of Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Patients With Advanced Heart Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00595738

Enrollment

Registered

2008-01-16

Start date

2007-12-31

Completion date

2011-01-31

Last updated

2011-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congestive Heart Failure

Keywords

Congestive heart failure, Cardiac biomarkers, Hemodynamics, Tailored therapy

Brief summary

The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is not clear. We aim to determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure. We will determine the relationship between cardiac output measured via thermodilution and the Fick equation calculated using concurrent oxygen saturations from the distal PA, central vein, and peripheral vein. We also aim to examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.

Interventions

OTHERStandard of care therapy for severe decompensated heart failure

Standard of care therapy for severe decompensated heart failure

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

The following inclusion criteria will be utilized: 1. Age\>21 2. PA-catheter insertion for therapy of congestive heart failure decided upon by the attending cardiologist The following will be considered as

Exclusion criteria

for this study 1. Known or suspected septic shock or bacteremia 2. Active bleeding or HCT\<24% at baseline 3. Arterial oxygen saturation \<90% at baseline despite supplemental oxygen therapy. 4. Previous difficulty with venipuncture of upper extremity veins or the presence of a surgical arteriovenous fistula for hemodialysis 5. Insertion of the PA catheter through the femoral vein 6. Subjects unwilling or unable to provide written consent

Design outcomes

Primary

Measure	Time frame
To determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure.	Day 0-5 of 'tailored' heart failure therapy

Secondary

Measure	Time frame
To examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.	Days 0-5 of 'tailored' heart failure therapy

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026