Tongue Carcinoma
Conditions
Keywords
Tongue, Carcinoma, Cancer, 02-093
Brief summary
The purpose of this study is to see how the brain re-learns to control the tongue in speaking and swallowing when either portions of the tongue have been removed, or when the tongue has been treated with radiation, in order to treat cancer. We hope the results of this study will help us to improve healing for patients who are being treated for cancer of the tongue. When patients with cancer of the tongue are treated by removing parts of the tongue (surgery) or by destroying the cancer with radiation to the tongue, they have significant difficulty speaking and swallowing after such treatments. At this time, patients who have been treated for cancer of the tongue re-learn speaking and swallowing through exercises taught by a speech pathologist. What is needed is information on how the brain re-learns to control speaking and swallowing so that we can help these patients re-learn faster after their treatments.
Detailed description
The purpose of this investigation is to determine cortical mechanisms of adaptation to surgical or radiation treatment to the tongue. This study will use a non-invasive imaging technique, Functional Magnetic Resonance Imaging (fMRI), to investigate cortical responses to partial glossectomy or radiation therapy for treatment of a tongue malignancy. Patients with Stage I-IV (AJCC) malignancies of the tongue who are treated with surgery and or radiation therapy will be imaged using fMRI pre-operatively and at approximately six months postoperatively. Patterns of brain activity from the fMRI studies will be compared with matched healthy control subjects. The results of this investigation will provide needed information on both central and peripheral mechanisms of adaptation.
Interventions
PROCEDUREMRI
Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging
Sponsors
Rockefeller University
New York Presbyterian Hospital
Memorial Sloan Kettering Cancer Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria for the tongue carcinoma patients: * Primary malignancy of the oral or base of tongue, Stage I-IV of AJCC staging system, planned for surgical or radiation therapy. Inclusion criteria for the healthy subjects: * Healthy adult subjects between the ages of 21-75 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To utilize fMRI to characterize adaptation to alterations in tongue morphology & function following either surgical therapy, or radiation/chemotherapy to tongue in patients undergoing treatment of malignancies involving the tongue. | 7 years |
Secondary
| Measure | Time frame |
|---|---|
| Determine relationship between mechanisms of adaptation at level of central nervous system to alterations in function in the tongue. | 7 years |
| Determine changes in cortical activity in representation of tongue movement that occur pre and post-treatment. | 7 years |
| Determine the central neural response to direct peripheral rehabilitation strategies. | conclusion of study |
Countries
United States
Outcome results
None listed