In Vitro Fertilization
Conditions
Keywords
aneuploidies in 7 chromosomes increased with advanced maternal age
Brief summary
In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS. In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.
Interventions
PROCEDUREPreimplantation genetic screening after embryo biopsy
Preimplantation genetic screening after embryo biopsy
Sponsors
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* All couples with a medical indication for IVF and with a female age of at least 35 years are invited to participate in the study.
Exclusion criteria
* Cycles were excluded from the study if ≤ 2 fertilized oocytes were available on day 1 after oocyte retrieval (OR), or if ≤ 2 ≥ 6c stage embryos were available on day 3 after OR.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical implantation rate per embryo transferred | end of study |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate per transfer | end of study |
Countries
Belgium
Outcome results
None listed