Effect of Changing Diet on Fasting and Post Fat Load Lipoproteins

Effect of Changing the Diet to Low Fat/High Carbohydrate or High Monounsaturated Fat/Low Carbohydrate on Fasting and Post Fat Load Lipoproteins of Diabetics With Moderate Hypertriglyceridemia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00593424

Enrollment

Registered

2008-01-15

Start date

2002-08-31

Completion date

2005-11-30

Last updated

2011-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Hypertriglyceridemia

Brief summary

The study examines the effect of two diets on fasting and post fat load lipoproteins of subjects with type 2 diabetes with moderate hypertriglyceridemia.

Interventions

OTHERLow Fat/High Carbohydrate

Low Fat/High Carbohydrate for 6 week period

OTHERHigh Monounsaturated Fat/Low Carbohydrate

High Monounsaturated Fat/Low Carbohydrate for 6 week period

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Male and female, * 18 - 75 years of age * Type 2 diabetes * Fasting triglycerides 300 -800mg/dL

Design outcomes

Primary

Measure	Time frame
Paired t-test or Wilcoxon signed rank test will be used to evaluate the change in fasting triglycerides with the diets.	At the beginning and end of each of the two diet regimens

Secondary

Measure	Time frame
Post-prandial lipids will be evaluated by t-test or Wilcoxon signed rank test for AUC of triglyceride and remnant lipoprotein measured by immunoseparation.	At the beginning and end of each of the two diet regimens

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026