International Registry and Biorepository for TMA(Thrombotic Microangiopathy)

An Observational Study of All Forms of Thrombotic Microangiopathy in Pediatric Patients

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00593229

Enrollment

Registered

2008-01-14

Start date

2007-01-31

Completion date

Unknown

Last updated

2013-06-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemolytic Uremic Syndrome, Thrombotic Microangiopathy, Thrombotic Thrombocytopenic Purpura

Keywords

Thrombotic microangiopathy (TMA), Hemolytic uremic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP)

Brief summary

This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy

Detailed description

Children age, 6 months - 18 years, are eligible if they have one of the following categories of thrombotic microangiopathy (TMA):(1) severe D+HUS; (2) non-familial atypical HUS; (3) familial atypical HUS; or (4) TTP Patients are seen intially and annually thereafter Biosamples are collected for storage annually.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Severe HUS, familial or non-familial atypical HUS, TTP

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame
Determine epidemiology and outcomes of the various forms of TMA	Ongoing
Determine genetic causes of TMA	Ongoing

Secondary

Measure	Time frame
Initiate clinical trials in TMA	In the future

Countries

United States

Outcome results