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Diagnosis Of Vertigo With New Imaging

New Diagnosis Of Vestibular Vertigo With Functional MRI

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00593216
Enrollment
4
Registered
2008-01-14
Start date
2007-07-31
Completion date
2008-12-31
Last updated
2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vertigo

Keywords

functional magnetic Resonance Imaging, vertigo, vestibular

Brief summary

The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.

Detailed description

The incidence of vertigo has been reported to be as high as 1.5% in the general population and some reports suggest that more than 5% of adults experience some kind of vertigo each year. In 80% of affected individuals, this symptom resulted in a medical consultation, interruption of daily activities, or sick leave. Therefore, vertigo can have a significant impact on health and well being. Unfortunately, there is not yet any satisfactory objective method for diagnosis of vertigo. At present, the diagnosis usually depends on medical history, vestibular function tests, Dix-Hallpike positioning tests done in the office, and, to some extent imaging studies doen to look for such abnormalities such as acoustic tumor, brain tumor, and evidence of multiple sclerosis. A number of recent studies support the possibility of using functional MRI (fMRI), particularly a new diffusion tensor fiber tracking (DTT) technique, as a new tool for diagnosis of disorders that can cause vertigo. In this study, our hypothesis is that there is an alteration in the activity in neural pathways of patients with vertigo that can be detected by fMRI. To test this assumption, our objective in this study is to determine whether there is a difference between the fMRI images obtained in normal subjects versus those in patients with vertigo.

Interventions

DEVICEFunctional MRI imaging

The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.

Sponsors

Boston University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Healthy volunteer or patient with symptom of vertigo

Exclusion criteria

* Evidence of mental impairment * Any type of bioimplant or any type of ferromagnetic bioimplant * Pregnant females * Exhibit noticeable anxiety and/or claustrophobia * History of serious disease in central nervous and cerebrovascular systems.

Design outcomes

Primary

MeasureTime frame
Activation of target sites on the functional MRI images during the vestibular responseNot specific

Secondary

MeasureTime frame
Differences in the fiber tracking of central nervous system specifically involved in the vestibular responseNot specific

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026