Leptospirosis
Conditions
Keywords
Severe leptospirosis, Pulmonary hemorrhage
Brief summary
Background: Pulmonary involvement in leptospirosis has been reported to be on the increase and is emerging as the main cause of death due to leptospirosis in many countries, including Thailand. Methods: A prospective randomized controlled trial of desmopressin or high dose dexamethasone as adjunctive therapy in patients with suspected pulmonary hemorrhage associated with leptospirosis was conducted between July 2003 and October 2006 at 5 hospitals in Thailand.
Interventions
DRUGDexamethasone, desmopressin
200 mg of dexamethasone IV infusion OD for 3 days or 0.3 microgram/ kg of desmopressin in 50 ml of saline, as a 30- minute infusion
Sponsors
Thailand Research Fund
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* adult patients (\> 14 years) with suspected severe leptospirosis * patients who presented with acute fever (oral temperature more than 38.00 C for \<15 days) in the absence of an obvious focus of infection * In the opinion of the attending physician might have pulmonary hemorrhage (i.e. history of hemoptysis, and/ or bilateral nodular or air space infiltration).
Exclusion criteria
* pregnant or breastfeeding * those with history of bleeding disorder * those who had underlying diseases such as chronic liver disease, diabetes mellitus * those who received diuretic or glucocorticoid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival | during in hospital admission |
Secondary
| Measure | Time frame |
|---|---|
| Days of mechanical ventilation | during hospital admission |
Countries
Thailand
Outcome results
None listed