Hodgkin's Disease, Pediatric
Conditions
Keywords
Pediatric, Hodgkin's Disease, 96-016
Brief summary
Study Hypothesis: Clinical staging without laparotomy/splenectomy is adequate for children and young adults with Hodgkin's disease who receive chemotherapy as a component of treatment.
Interventions
DRUGCOPP/ABV
4 courses of COPP/ABV hybrid
DRUGintensive chemo with concurrent growth factor
6 cycles (2 courses) of intensive chemotherapy with concurrent growth factor
Sponsors
Children's Cancer Group
Memorial Sloan Kettering Cancer Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 21 Years
Healthy volunteers
No
Inclusion criteria
* Age less than 21 years at diagnosis * Previously untreated, pathologically confirmed diagnosis of Hodgkin's disease. * Informed patient/parental consent as required by individual institution and in accordance with the Dept of Health and Human Services * Approval of this protocol by the individual institutional Human Subjects Review Committee. * Indicate Hodgkin's disease clinical stage. * Indicate presence or absence of B symptoms. * For Stage I and II disease indicate the following: * presence or absence of bulk disease * number of involved nodal regions * presence or absence of hilar adenopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the role of adjuvant low dose involved field radiotherapy in pediatric patients with Hodgkin's disease who attain a complete response following initial chemotherapy | Conclusion of the study |
Countries
United States
Outcome results
None listed