COPD
Conditions
Keywords
COPD oxygen, COPD rehabilitation, exercise
Brief summary
In COPD patients with desaturation during exercise, several studies have shown an acute beneficial effect of supplemental oxygen. Therefore, both the British Thoracic Society and the American Thoracic Society guidelines recommend supplemental oxygen to patients who desaturate \>4% and to below 88-90%. However, long-term studies have not been able to support this intervention. In this study of COPD patients, who desaturate and participate in a 7-week pulmonary rehabilitation programme, we examine the effect of supplemental oxygen on exercise tolerance, health status, and exacerbation rates. In a randomised design patients trained either with room air or with 2 litres oxygen per minute from a portable oxygen concentrator. All patients were asked to exercise every day for 30 minutes.
Detailed description
In COPD patients with desaturation during exercise, several studies have shown an acute beneficial effect of supplemental oxygen. Therefore, both the British Thoracic Society and the American Thoracic Society guidelines recommend supplemental oxygen to patients who desaturate \>4% and to below 88-90%. However, long-term studies have not been able to support this intervention. In this study of COPD patients, who desaturate and participate in a 7-week pulmonary rehabilitation programme, we examine the effect of supplemental oxygen. Using a randomised design, patients trained either with room air (control) or with 2 litres oxygen per minute from a portable oxygen concentrator. All patients were asked to exercise every day for 30 minutes. Primary effect parameters: endurance shuttle walk time at baseline, 7 weeks (after intensive supervised rehabilitation), 3 months (after maintenance training twice a month), and after 6 months. Secondary effect parameters: St. George Respiratory Questionnaire (health status); usage of oxygen, exacerbations requiring medical treatment, hospitalisation and mortality in the same periods.
Interventions
OTHERoxygen from a portable concentrator
2 l/minute during exercise
Sponsors
Danish Lung Association
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COPD * participate in a 7-weeks pulmonary rehabilitation programme * desaturate \>4% to less than 90% during endurance shuttle walk test
Exclusion criteria
* long-term oxygen therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shuttle walk (endurance time) | 7 week, 3 and 6 months |
Secondary
| Measure | Time frame |
|---|---|
| St. George Respiratory Questionnaire | 7 week, 3 and 6 months |
| Usage of oxygen concentrator (Spent time according to the meter) | 7 weeks, 3 and 6 months |
| Exacerbations requiring medical treatment (prednisolone or antibiotics) | 7 weeks, 3 and 6 months |
| Hospitalisation | 7 weeks, 3 and 6 months |
| Mortality | 7 weeks, 3 and 6 months |
Countries
Denmark
Outcome results
None listed