Burn
Conditions
Keywords
burn, donor site, grafting, scar
Brief summary
Primary research questions/Purpose of the Research. 1. Determine the short term (epidermal regeneration, reduction of pain, infections and length of stay) and long term (scarring, long term recovery, and cost of treatment) outcomes of Microbial Nanocellulose (NC) and fine mesh gauze impregnated with hyaluronan and thrombin (HT). 2. Determine if donor site treatment with NC and HT is as safe as the use of Scarlet Red ointment dressing. b. Describe the importance of the knowledge that you expect to gain from the research. To find a donor site dressing that has outcomes equal or better than that of scarlet red.
Interventions
DRUGApplication of donor site dressing [scarlet red, Microbial Nanocellulose (NC), or hyaluronan and thrombin (HT)]
Application of donor site dressing: scarlet red, Microbial Nanocellulose (NC), or hyaluronan and thrombin (HT).
PROCEDUREBlood sample
Obtain blood specimen at surgery donor site harvest, 14 days post surgery and 6 months post surgery
PROCEDUREBiopsy
Tissue biopsy of donor site treated area at admission, wound healing and 2-6 months post burn.
Sponsors
The University of Texas Medical Branch, Galveston
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 90 Years
Healthy volunteers
No
Inclusion criteria
* Ages 0-90 years. * Any patient admitted to the hospital with burn injury requiring grafting and a donor site.
Exclusion criteria
* Patient with severe burn injuries expected to die.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| epidermal regeneration (donor site healing) | Days 3-14 post surgery |
Secondary
| Measure | Time frame |
|---|---|
| Infection | Days 0-21 post surgery |
| reduction in pain of donor site | Day 0-21 post surgery |
| Scarring | Day 7 post surgery to 2 years post surgery |
| Costs | Admission post burn injury to 2 years post burn injury |
Outcome results
None listed