GI Colonization of Vancomycin-resistant Enterococcus
Conditions
Keywords
VRE, Probiotics, colonization, gut health
Brief summary
Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).
Interventions
DIETARY_SUPPLEMENTprobiotics
100 gms of a yogurt drink containing probiotics will be given to pVRE positive patients for 4 weeks
DIETARY_SUPPLEMENTyogurt
100 gms of pasteurized yogurt drinks with no live cultures will be given to VRE positive patients for 4 weeks
Sponsors
Oregon Health and Science University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* VRE positive patients with GI colonization
Exclusion criteria
* Age less than 18 years * Patients who have had a bone marrow transplant * Extreme short bowel patients (less than 100 cm small bowel remaining) * Patients with active VRE infection but no GI colonization * Patients unable to eat and have no feeding access * Patients who do not have a power of attorney to give consent if they are unable to
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether a positive VRE colonized patient becomes VRE negative after drinking yogurt with probiotics | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Time to VRE clearance | 4 weeks |
| Sustainable effects of probiotics on VRE colonization | 8 weeks |
| Any positive or negative effects on patients' hospital stay. | 8 weeks |
Countries
United States
Outcome results
None listed