Healthy
Conditions
Keywords
dietary salt, sodium, blood vessels, vascular function, endothelial function, heart disease risk, cardiovascular disease risk
Brief summary
The purpose of this study is to look at the effects of high- and low-salt diets on blood vessel function in healthy subjects.
Detailed description
Healthy volunteers will be enrolled in a dietary sodium intervention to examine impact on vascular function.
Interventions
DIETARY_SUPPLEMENTHigh sodium
DIETARY_SUPPLEMENTLow sodium
Sponsors
Brigham and Women's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy male, African-American volunteers 2. 18-35 years of age, 3. No personal or first degree relative with hypertension or diabetes, 4. Blood pressure \<130/85 mmHg and \> 90/60 at the screening visit, 5. Body mass index \<30 kg/m2, 6. No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).
Exclusion criteria
1. Alcohol intake \>2 beverage/night, 2. Smoking, 3. Recreational drug use, 4. Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months, 5. Prescription or herbal medication use, 6. Ischemic changes on resting electrocardiogram, 7. Known hypersensitivity to any of the study drugs, 8. Other active medical problems detected by examination or laboratory testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endothelial function | one week |
Countries
United States
Outcome results
None listed